Information Systems (IS) and the process of distinguishing Information Systems ontology have been the center of challenge during the 50 years of IS development. The importance of this challenge is emergent in direct link between knowledge development process in IS and the IS ontology. In other words, theorizing and efforts to falsify theories, which have been developed, is influenced by the way IS ontology is approached. Critical realism enjoying the unique approach to the IS ontology based on

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... ranscendental realism and critical naturalism can be a useful basis to establish the transdisciplinary view in the process of IS knowledge development. This point of view is important regarding the role of human agent in different layers of the IS ontology as a result of its transcendental ontology. Critical realism develops human role during next stages of knowledge and the methodology development based on the transdisciplinary view to IS. The explanation of a transdisciplinary view to the IS ontology regarding the unique role of human agent in the process of theorizing and knowledge development in Information Systems is presented in this article.