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The segmentation of the cortical interface between grey and white matter in magnetic resonance images (MRI) is highly challenging during the first post-natal year. First, the heterogeneous brain maturation creates important intensity fluctuations across regions. Second, the cortical ribbon is highly folded creating complex shapes. Finally, the low tissue contrast and partial volume effects hamper cortex edge detection in parts of the brain. Methods and Findings: We present an atlas-free methoddoi:10.1371/journal.pone.0027128 pmid:22110604 pmcid:PMC3217936 fatcat:i52g3h5m5jdd3gadaxfn6andgu