IL-1β polymorphism in copd patients in Turkish population
Türk popülasyonundaki koah hastalarında IL-1β polimorfizmi

Onur Baykara, Nuriye Banu Tömekçe Taşkıran, Şadan Soyyiğit, Nur Buyru
2017 Turkish Journal of Tuberculosis & Thorax  
Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by persistent airflow limitation and is associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Interleukin-1 beta (IL-1β) is a major pro-inflammatory cytokine expressed by many cells such as macrophages, neutrophils and monocytes and functions in cellular activities such as proliferation, differentiation and apoptosis. Recent studies
more » ... te controversial results about the relationship between IL-1β and COPD. The aim of this study is to investigate the association between IL-1β -511 (rs 16944) and +3954 (rs 1143634) gene polymorphisms and COPD in Turkish population. patients and Methods: A total of 152 subjects were recruited in the study and divided into three groups: 72 COPD patients, 41 healthy smokers and 39 never-smokers. PCR-RFLP method was used to determine the allele frequencies, genotype and haplotype distributions. Results: We did not find any significant difference between the gene polymorphisms and COPD by means of genotype frequencies, haplotype association, stage, gender or smoking status (p< 0.05). conclusion: Our results do not show any evidence of association between COPD and IL-1β -511 and +3954 gene polymorphisms in Turkish population. ÖZET Türk popülasyonundaki KoAh hastalarında IL-1β polimorfizmi Giriş: Kronik obstrüktif akciğer hastalığı (KOAH) persistan hava akım kısıtlanması ile karakterize sık görülen bir hastalıktır. Çeşitli zararlı gaz ve partiküller hava yollarında kronik inflamasyona neden olurlar. İnterlökin-1 beta (IL-1β), makrofajlar, nötrofiller ve monositler gibi birçok hücre tarafından üretilen ana pro-
doi:10.5578/tt.52778 pmid:28990887 fatcat:js6jh3zk5bhank36kvjdo55svm