Features of SARS-COV-2 infection and directions of drug and vaccine creation

A.Yu. Volyansky, T.V Davydova, M.V. Kuchma, I.P. Yudin, Kuchma. I.Yu.
2020 Zenodo  
Until the beginning of the 21st century human coronaviruses were known as the cause of typical seasonal аcute respiratory disease. Highly pathogenic coronaviruses were identified as the cause of severe acute respiratory syndrome (SARS) with high mortality in 2002 – SARS-CoV, and then in 2013 as the causative agents of Middle East respiratory syndrome – MERS-CoV. They have caused severe respiratory disease in humans because of their ability to adapt to the host, increasing affinity for human
more » ... inity for human airway receptors. The emergence a new coronavirus in 2019 caused a rapid increase in the incidence of severe acute respiratory syndrome and turned into a pandemic. Background: The new coronavirus SARS-CoV-2, which causes Covid-19 (coronavirus infection disease), was first detected in December 2019 in Wuhan, the capital of Hubei province, from where it quickly spread to China and continued to spread to Italy and other countries of Europe and after around the world, the number of confirmed new cases is increasing daily. Rationale: Coronaviruses are members of the order Nidovirales of the family Coronaviridae and divided into 4 genera: α- and β-coronavirus, which infect only mammals, and γ- and δ-coronavirus, which mainly affect birds. The central place is occupied by the genus β-coronavirus, which includes especially dangerous pathogens of lethal human pneumonia – SARS-CoV, MERS-CoV, SARS-CoV2. In turn, β-coronavirus divided into four subgenres: A, B, C, D. SARS-CoV-2 is β-coronavirus, subgroup B, Sarbecovirus. Coronaviruses affecting humans currently have 7 species. They divide into 2 groups. 1st group has 4 common types of coronaviruses that cause about 15% of typical seasonal SARS: HCoV-229E, NL63, OC43 and HKU1. Usually these types cause mild forms of upper respiratory tract diseases in children (and less often in adults), but in some cases (like other SARS viruses) cause interstitial pneumonia (in newborns, children with immunodeficiency, people wit [...]
doi:10.5281/zenodo.4382121 fatcat:6htcmz35yrazpmwtehjlff6hmm