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Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy
2020
Proceedings of the National Academy of Sciences of the United States of America
The chaperone protein SmgGDS promotes cell-cycle progression and tumorigenesis in human breast and nonsmall cell lung cancer. Splice variants of SmgGDS, named SmgGDS-607 and SmgGDS-558, facilitate the activation of oncogenic members of the Ras and Rho families of small GTPases through membrane trafficking via regulation of the prenylation pathway. SmgGDS-607 interacts with newly synthesized preprenylated small GTPases, while SmgGDS-558 interacts with prenylated small GTPases. We determined that
doi:10.1073/pnas.1914153117
pmid:32019878
fatcat:x26rooeianabnhseeafacczrge