Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently

Andrew Currin, Neil Swainston, Philip J. Day, Douglas B. Kell
2015 Chemical Society Reviews  
Improving enzymes by directed evolution requires the navigation of very large search spaces; we survey how to do this intelligently.
doi:10.1039/c4cs00351a pmid:25503938 pmcid:PMC4349129 fatcat:4alcgtju6jfdrj7ditdnurs4qq