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The present study was undertaken to investigate the effects of long term administration of valproate that is commonly used in clinics and co-administration of alfacalcidol or alendronate with valproate on bone metabolism in growing rats. Bone mineral densities and serum bone makers were determined. The samples obtained from tibial metaphysis were then prepared for histological observation. As the results, valproate decreased the bone mineral density in both metaphysis and diaphysis with dosedoi:10.2485/jhtb.14.275 fatcat:b4gpwuul55d4xaosn5tbmsqnxm