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Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells
2020
Genome Biology
H3K27ac is well recognized as a marker for active enhancers and a great indicator of enhancer activity. However, its functional impact on transcription has not been characterized. By substituting lysine 27 in histone variant H3.3 with arginine in mouse embryonic stem cells, we diminish the vast majority of H3K27ac at enhancers. However, the transcriptome is largely undisturbed in these mutant cells, likely because the other enhancer features remain largely unchanged, including chromatin
doi:10.1186/s13059-020-01957-w
pmid:32085783
fatcat:xvoocdxskjfo5os65pjm5tfwuu