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Cell biologists are interested in how complexity arises from the interaction of different molecules. However, cells are many orders of magnitude larger than the protein-binding interfaces. To bridge these vast difference in scales, biologists construct hierarchies of organization of cellular structures. I describe how systems biology provides an approach to bridge these different scales.doi:10.1098/rstb.2011.0074 pmid:22084389 pmcid:PMC3203457 fatcat:uixt2sgaznemxmdaxg5icdqkhq