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AbstractProgesterone and allopregnanolone have crucial and different roles in brain development, function and recovery after injury. Pregnancy is characterized by an increased synthesis of progesterone and its neuro-active metabolites by the placenta, maternal and fetal brain. This supports the critical role of these steroids in maternal brain adaptation during pregnancy and development of the fetal brain. Moreover, allopregnanolone may play a brain-protective role during complications ofdoi:10.1515/hmbci-2016-0020 pmid:27442421 fatcat:pdeyl6vrkza6tadsugfpatbndi