COVID-19, cytokine storm and sigma-1 receptors: potential treatments at hand? [post]

Lanfranco R Troncone
2020 unpublished
Fluvoxamine, a usual SSRI antidepressant, has agonistic activity on Sigma-1 receptors in ER and inhibits IRE1, an important trigger of cytokine production; Sigma-1 receptor is a target of SARS-COV-2 protein Nsp6 and may start the cytokine storm.
doi:10.22541/au.159335613.31156244 fatcat:333uyucn2jealklom35g7vdo64