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High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth
Toxoplasma gondii is an obligate intracellular parasite capable of causing severe disease due to congenital infection and in patients with compromised immune systems. Control of infection is dependent on a robust Th1 type immune response including production of interferon gamma (IFN-γ), which is essential for control. IFN-γ activates a variety of anti-microbial mechanisms in host cells, which are then able to control intracellular parasites such as T. gondii. Despite the effectiveness of thesedoi:10.1101/336818 fatcat:doydrivfmzba5crodamswg3zmi