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The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones
[article]
2020
bioRxiv
pre-print
The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across physiological human tissues has received little attention. Here, we used human tissue RNA-sequencing profiles to analyze the expression and organization of chaperones across 29 main tissues. We found that relative to protein-coding genes, chaperones were significantly more ubiquitously and highly expressed across all tissues.
doi:10.1101/2020.03.04.976720
fatcat:kf5prvmklzcbrig4x74s2je34u