Mouse model of systemic lupus erythematosus (SLE) induced by nucleic acid–containing amyloid fibrils

2012 Science-Business eXchange  
Approach Summary Licensing status Publication and contact information Disease models Mouse model of systemic lupus erythematosus (SLE) induced by nucleic acid-containing amyloid fibrils A mouse model of SLE induced by nucleic acid-containing amyloid fibrils could help screen and evaluate potential lupus therapies. In healthy mice, immunization with DNA-containing amyloid fibrils induced a rapid interferon response, infiltration of plasmacytoid dendritic cells (pDCs) at the inoculation site,
more » ... antibody production and proteinuria. In those mice, mAb-mediated depletion of pDCs decreased the interferon response and amyloid fibrilinduced generation of several autoantibodies compared with IgG control. Next steps include developing additional SLE models using delivery of different types of amyloids to generate different types of autoantibodies.
doi:10.1038/scibx.2012.882 fatcat:ogp7ue32ovbx7ouuq6npktitji