Pdcd4 targets eIF4A to inhibit translation, transcription, tumorigenesis, and invasion

Nancy H. Colburn, Hsin-Sheng Yang, Aaron Jansen
2006 EJC Supplements  
preproGRP transcripts were found in 28% of the blood samples. The detection of a hematogenic tumor cell spread with preproGRP in MTC correlated significantly with advanced tumor categories. CK20 transcripts were detected in 75% of the blood samples of patients with thyroid carcinoma and distant metastases. Moreover disseminated tumor cells were detected in 21% of the bone marrow samples with CK20-PCR and 13% with preproGRP (only for MTC). Conclusion: Both assays are sensitive enough to detect
more » ... sseminated thyroid carcinoma cells in blood and bone marrow samples. However, the prognostic relevance of these disseminated tumor cells is not completely understood and has to be addressed in further investigations.
doi:10.1016/j.ejcsup.2006.04.053 fatcat:7f7ahdlhgjez3dfgucrjgm2hki