Retrospective study of risk factors for severe SARS-Cov-2 infections in hospitalized adult patients

Qingchun Yao, Peng Wang, Xingguang Wang, Guoqiang Qie, Mei Meng, Xiwen Tong, Xue Bai, Min Ding, Weiming Liu, Keke Liu, Yufeng Chu
2020 Polish Archives of Internal Medicine  
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spread worldwide. To identify the clinical characteristics and risk factors associated with the severe incidence of SARS-CoV-2 infection. All adult patients (≥18 years old) consecutively admitted in Dabieshan Medical Center from January 30, 2020 to February 11, 2020 were collected and reviewed. Only patients diagnosed with COVID-19 according to WHO interim guidance were
more » ... erim guidance were included in this retrospective cohort study. A total of 108 patients with COVID-19 were retrospectively analyzed. Twenty-five patients (23.1%, 25/108) developed severe disease, and of those 12 (48%, 12/25) patients died. Advanced age, co-morbidities with hypertension, higher blood leukocyte count, neutrophil count, higher sensitive C-reactive protein level, D-dimer level, Acute Physiology and Chronic Health Evaluation Ⅱ (APECHE Ⅱ) score and Sequential Organ Failure Assessment (SOFA) score were associated with greater risk of development of severe COVID-19, and so were lower lymphocyte count and albumin level. Multivariable regression showed increasing odds of severe COVID-19 associated with higher SOFA score (OR 2.450, 1.302-4.608; p = 0.005), and lymphocyte count less than 0.8×109 per L (OR 9.017, 2.808-28.857; p <0.001) on admission. The higher SOFA score (OR 2.402, 1.313-4.395; p = 0.004) on admission was identified as risk factor for in-hospital death. Lymphocytopenia and the higher SOFA score on admission could help clinicians to identify patients with high risk for developing severe COVID-19. More related studies are needed in the future.
doi:10.20452/pamw.15312 pmid:32329978 fatcat:zl7imyvje5eylmbhj3bjfsmvwy