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Effect of hind limb immobilization on the lysosomal enzyme activity in the rat skeletal muscle
One week-immobilization of rat soleus muscle in a shortened position caused muscle atrophy with decreasing amounts of both structural and cytosolic proteins. On the other hand, soleus muscle immobilized in a lengthened position slightly gained weight with increasing amounts of proteins. In both cases, the specific activity of lysosomal enzymes including cathepsin D and other acid hydrolases increased significantly, but that of cytosolic enzymes including neutral and alkaline proteases remaineddoi:10.2220/biomedres.4.597 fatcat:pjqwb6i6ojap5jngpdpil6orwy