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The Roles of Membrane Transporters on the Oral Drug Absorption
Journal of Molecular Pharmaceutics & Organic Process Research
Oral drug absorption is usually dependent on drug's physicochemical properties, formulation design and physiological conditions of gastrointestinal tract  . It is well known that physicochemical properties of drugs, like molecular weight, crystal structure, lipophilicity, pKa could generally determine the absorption mechanism . Physiological conditions of gastrointestinal tract, i.e., expression level of drug metabolizing enzymes (polymorphism), empty/transit of GI tract, food effect, anddoi:10.4172/2329-9053.1000e102 fatcat:pqhiop5gknhsbpteb7mdcskzdm