Evolution and disorder

Celeste J Brown, Audra K Johnson, A Keith Dunker, Gary W Daughdrill
2011 Current Opinion in Structural Biology  
The evolution of disordered proteins or regions of proteins differs from ordered proteins because of the differences in their sequence composition, intramolecular contacts and function. Recent assessments of disordered protein evolution at the sequence, structural and functional levels support this hypothesis. Disordered proteins have a different pattern of accepted point mutations, exhibit higher rates of insertions and deletions, and generally, but not always, evolve more rapidly than ordered
more » ... proteins. Even with these high rates of sequence evolution, a few examples have shown that disordered proteins maintain their flexibility under physiological conditions, and it is hypothesized that they maintain specific structural ensembles.
doi:10.1016/j.sbi.2011.02.005 pmid:21482101 pmcid:PMC3112239 fatcat:bcdpcdahlzejvjgzttzdduooru