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The evolution of disordered proteins or regions of proteins differs from ordered proteins because of the differences in their sequence composition, intramolecular contacts and function. Recent assessments of disordered protein evolution at the sequence, structural and functional levels support this hypothesis. Disordered proteins have a different pattern of accepted point mutations, exhibit higher rates of insertions and deletions, and generally, but not always, evolve more rapidly than ordereddoi:10.1016/j.sbi.2011.02.005 pmid:21482101 pmcid:PMC3112239 fatcat:bcdpcdahlzejvjgzttzdduooru