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Brazilian spotted fever (BSF), a lethal tick-borne Rickettsioses (2000 -2018 >600 human deaths) involving synanthropic capybara as host. Methods: We introduced an alternative to mitigate human-capybara conflicts and epidemiologic concerns of BSF. Complex aspects like transmission dynamics, risk areas, host mobility, and birth rate control, were considered to develop a prevention strategy using an anti-GnRH vaccine. Results: The propositioned immunocontraceptive potentially remove and preventdoi:10.1590/0037-8682-0156-2019 fatcat:2slxfplpmndafo3tpk7qeegu7i