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The FOXO family of transcription factors constitutes an evolutionarily conserved subgroup within the larger family known as winged helix or Forkhead transcriptional regulators. Building upon work in the nematode, researchers have uncovered a role for these proteins in a diverse set of cellular responses that include glucose metabolism, stress response, cell cycle regulation, and apoptosis. At the organismal level, FOXO transcription factors are believed to function in various pathologicaldoi:10.1126/stke.2003.172.re5 pmid:12621150 fatcat:ys2v6obceja53fm7m2co5fhf7q