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We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marker loci. Markers were amplified by the PCR using fluorescencetagged primers and sized based on the difference of CA repeats on DNA. Linkage analysis was made using maximum lod scoredoi:10.1093/intimm/10.12.1891 pmid:9885910 fatcat:hgdrd4il7fga3fs25hvidhljei