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Nonsense-mediated mRNA decay at the crossroads of many cellular pathways
2017
BMB Reports
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Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other cell processes which regulate or activate it under specific cell conditions or in response to mutations, mis-regulations, stresses, or particular cell programs. These cell processes
doi:10.5483/bmbrep.2017.50.4.015
fatcat:yjtb56m3ffhkrbjwcqdohlatse