Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy

Georg Oeltzschner, Nicolaas A.J. Puts, Kimberly L. Chan, Vincent O. Boer, Peter B. Barker, Richard A.E. Edden
2016 Magnetic Resonance in Medicine  
Purpose-To develop J-difference editing with Parallel Reconstruction in Accelerated Multivoxel (PRIAM) for simultaneous measurement of γ-aminobutyric acid (GABA) and glutathione in two separate brain regions. Methods-PRIAM separates signals from two simultaneously excited voxels using receiver-coil sensitivity profiles. PRIAM was implemented into Mescher-Garwood-(MEGA)-edited experiments at 3T, and validated by acquiring dual-voxel MEGA-PRIAM (and compared to conventional single-voxel
more » ... ) spectra from a GABA/glutathione phantom, and 11 healthy participants. Results-MEGA-PRIAM effectively separated phantom spectra with ~3-4% between-voxel contamination. GABA and glutathione measurements agreed well with those obtained using single-voxel MEGA-PRESS (mean difference was below 2% in GABA levels, and below 7% in glutathione levels). In vivo, GABA-and glutathione-edited spectra were successfully reconstructed with a mean in vivo g-factor of 1.025 (typical voxel-center separation: 7-8 cm). MEGA-PRIAM experiments showed higher signal-to-noise than sequential single-voxel experiments of the same total duration (mean improvement 1.38±0.24). Conclusions-Simultaneous acquisition of J-difference-edited GABA or glutathione spectra from two voxels is feasible at 3T. MEGA-PRIAM increases data acquisition rates compared to MEGA-PRESS by a factor of 2.
doi:10.1002/mrm.26536 pmid:27851878 pmcid:PMC5422131 fatcat:5mlrtbtddzb2hlitlrzs6z3rqu