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ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration
[article]
2020
biorxiv/medrxiv
pre-print
Animals have evolved multiple mechanisms to protect themselves from the cumulative effects of age-related cellular damage. Here we reveal an unexpected link between the TNF (tumour necrosis factor) inflammatory pathway, triggered by the metalloprotease ADAM17/TACE, and a lipid droplet (LD)-mediated mechanism of protecting retinal cells from age related degeneration. Loss of ADAM17, TNF and the TNF receptor Grindelwald in pigmented glial cells of the Drosophila retina leads to age related
doi:10.1101/2020.01.09.900209
fatcat:jrupixwhdzgtzj5elliapns2ka