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Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits
2011
The 5-hydroxytryptamine (5-HT) system modulates numerous physiological and behavioural processes, and dysfunction within this system underlies many behavioural disorders, such as major depression. The 5-HT1A receptor is the primary somatodendritic autoreceptor that controls the firing rate of 5-HT neurons, but is also coupled to numerous signalling pathways. An understanding of 5-HT1A receptor signalling may lead to the development of antidepressant drugs that selectively target therapeutic
doi:10.20381/ruor-4418
fatcat:ifzkk2x2gzaztdujrvjmotpd3u