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Sildenafil is a selective type 5 phosphodiesterase (PDE5) inhibitor, commonly used in the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). The results of recent studies suggest that this drug modulates function of the immune system. However, only few studies were performed in humans. Therefore, the aim of this study was to investigate the ability of sildenafil to regulate the production of proinflammatory cytokines including tumor necrosis factor alpha (TNF-α),doi:10.32383/appdr/93121 fatcat:tut2x6msa5gptgwbhhgkkbub2e