Practical Preparation of Ethyl 2-Methylthiophene-3-carboxylate

Masakazu Kogami, Nobuhide Watanabe
2011 Chemical and pharmaceutical bulletin  
A safe and efficient process for the preparation of ethyl 2-methylthiophene-3-carboxylate (5) was devised. This process provides several advantages over the precedents, involving operational simplicity, avoidance of the use of strong bases such as n-butyllithium and application of noncryogenic conditions, and enabled to prepare 5 in 52% overall yield from commercially available 2-methylthiophene on a multikilogram scale.
doi:10.1248/cpb.59.797 pmid:21628923 fatcat:kbnclb7zubbxlb5xivmehb7vsu