High Potency Neuroleptics and Violence in Schizophrenics

JOHN N. HERRERA, JOHN J. SRAMEK, JEROME F. COSTA, SWATI ROY, CHRIS W. HEH, BICH N. NGUYEN
1988 Journal of Nervous and Mental Disease  
In a conti'olled stucly, inpatient violence was measured cluring placebo, high-potency (halopericlol) and lorv-potency (chlorpromazine or clozapine) neuroleptics. Some patients had a markecl increase in violent behavior rvith the mocleratelv high-dose haloperidol, but not u,ith lou,-potency neuroleptics. The authors cliscuss reasons for the inct'easecl vioience rvith halopericlol, inclucling al<athisia ancl clmg-induced behavioral toxicit.y.
doi:10.1097/00005053-198809000-00009 fatcat:wqfgc4o6x5bvjknb5nqmi3ip5a