Intravital Imaging

Mikael J. Pittet, Ralph Weissleder
2011 Cell  
Until recently, the idea of observing life deep within the tissues of a living mouse, at a resolution sufficient to pick out cellular behaviors and molecular signals underlying them, remained a much-coveted dream. Now, a new era of intravital fluorescence microscopy has dawned. In this Primer, we review the technologies that made this revolution possible and demonstrate how intravital imaging is beginning to provide quantitative and dynamic insights into cell biology, immunology, tumor biology, and neurobiology.
doi:10.1016/j.cell.2011.11.004 pmid:22118457 pmcid:PMC3824153 fatcat:c75zhkri5bhirh3rk2xkuiw2yy