time to time with spirits of turpentine, all painted surfaces were repainted, and Dr. Marfan recommended that the door should be swept in the evening after the departure of the employees, and that the windows should be left open all night. Dr. Vallin recommends in place of these measures a mixture of equal parts of coal-tar and spirits of turpentine, or of paratfine dissolved in warm petroleum, and, in place of the sweeping, the removal of the dust by sponges, or cloths moistened with a n

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... ptic solution. Tissue Metabolism in Cancer. Dr. F. Miiller has made some careful comparative observations upon the urine in cases of cancer and other wasting diseases, and in simple starvation. He finds, according to the London Lancet, that in the cancerous the excretion of nitrogen far exceeds the amount ingested, and infers that this excess must in consequence be derived from thedisintegration of the albuminoids of the body. However, in two out of seven cases this loss was not greater than occurred in other individuals similarly insufficiently nourished. The chlorides were, on the other hand, notably diminished,-a fact, he thinks, pointing to the source of the excreted nitrogen; vie., from the organ albumen, and not from the circulating albumen. Obviously, however, many diseases share, with carcinoma, in this disintegrating process, as Mf~ller showed to be the case in chronic febrile affections, especially severe forms of malaria, in leukzemia, and pernicious anzemia. Previous observers do not coincide in their statements on this head as regards leukzemia. Voit and Pettenkofer found no marked evidence of increased metabolism in this affection, and Fleischer and Penzoldt concurred in this so far as regards mild cases. But in severe cases the last-named find the urea to be increased both absolutely and relatively. Sticker and Klemperer arrived at the same conclusion. Respecting pernicious anzeruia, there is a concurrence of testimony in support of increased nitrogenous excretion. Reverting to cancer, this evidence, Miiller thinks, goes to prove that malignant disease excites the formation of metabolic products which are poisonous to the organism. He points out that cachexia develops in the cases of malignant growths, no matter how limited, and without their involving any important organ; whereas a non-malignant tumor may attain great dimensions without affecting the excretion of urea. At the same time no such poison or ferment destructive of albumen can be isolated from cancerous tumors, although the fact pointed out by Feltz, that the urine of the cancerous is more toxic to animals than that of healthy individuals, is, with other facts, highly suggestive of that view. Kola-Nut for Seasickness.