Activity of antioxidant enzymes and gelatinase in rats with epinephrine-induced miocardial ischemia

V. A. Parоnik, O. E. Shaulska, V. I. Zhylіuk, A. I. Shevtsova
2015 Medical and Clinical Chemistry  
<p>In this study we examined the activity of antioxidant enzymes and gelatinases in rats with epinephrine-induced<br />myocardial ischemia and the impact of corvitin (C) and doxycycline (D) on these indicators. The administration<br />of epinephrine (0.2 mg/100 g) for 10 days leads to an increase in lipid peroxidation and to the elevated activity of<br />antioxidant enzymes and gelatinases in blood and in the heart of experimental animals. Under application of C and<br />D activity of the
more » ... tivity of the enzymes was reduced, especially activity of SOD and gelatinases. Our data suggest that C and D<br />can reduce the cardiotoxic effects of high doses of epinephrine due to their ability to bind free radicals and to inhibit<br />the activity of matrix-degrading enzymes.</p>
doi:10.11603/mcch.2410-681x.2015.v17.i3.5055 fatcat:ylrr3iue6fazpd3xppiw427bkq