AB0444 СLINICAL-IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH INFLAMMATORY MYOPATHIES

A. Khelkovskaia-Sergeeva, O. Desinova, M. Starovoytova, L. P. Ananyeva, M. Cherkasova, R. Shayakhmetova
2021 Annals of the Rheumatic Diseases  
Background:Inflammatory disorders of the skeletal muscle include polymyositis (PM), dermatomyositis (DM), amyopathic dermatomyositis ADM, (immune mediated) necrotizing myopathy (NM), overlap syndrome with myositis (overlap myositis, OM) and including anti-synthetase syndrome (ASS).The detection of myositis-specific antibodies, the clinical effect of which remains to be determined, may be of great importance for diagnosis.Objectives:To study clinical-immunological characteristics of patients
more » ... ics of patients with inflammatory myopathies.Methods:57 pts were enrolled in this study: 28 (47%) pts were diagnosed with DM, 14 (23%) pts – OM, 5(8%) pts – PM, 5 (8%) pts-NM, 4 (7%) pts-ADM, 1 (2%)- ACC. Duration of disease in average 11,29 (2-48) month. Standard clinical examination and laboratory immunological evaluation including myositis-specific autoantibodies were performed.Results:There were 3 age groups: 18-39 years old – 16 (28%) pts, 40-49 yo – 28 (49%) pts and > 60 yo – 13 (33%) pts. Symptoms of myositis were muscle weakness 57 (100%) pts, dysphagia 29 (51%) pts, arthritis -12 (21%) pts, Raynaud's phenomenon 21 (37%) pts, skin lesions- 37 (65%) pts (Gottron signs- 7 (12%) pts, digital ulcers -11 (19) pts, panniculitis – 6(11%) pts, hand of mechanic 16(28%) pts). MMT 8 was 55,57 (SD 18,49) (20-80) score. Clinical features of myositis were myocarditis 8 (14%) pts and arrhythmia 9 (16%) pts, interstitial lung disease 20 (35%) pts, esophageal involvement 29 (51%) pts of them 5 (9%) pts needed enteral feeding. 2 (4%) pts had oncopathology. СК was increased in 49 (86%) pts: < 10 N -15 (26%) pts, >10 N – 28 (49%) pts, > 50 N – 6 (11%). ANA positive - in 39 (70%) pts. Antibodies identified in 25(44%) pts: Pm-Scl 7 (12%) pts, PL-7 1 (2%), Mi-2 10 (17,5%), Ku 2 (3,5%) pts, AMA-M2 2 (2%)pts, a-SRP 4 (7%) and SS-A/Ro-52 13 (23%), SS-A/Ro-60 2 (3%) pts.Conclusion:The group of inflammatory myopathies is characterized by clinical and immunological heterogeneity. Finding antibodies specific for myositis can help diagnose the disease.Disclosure of Interests:None declared.
doi:10.1136/annrheumdis-2021-eular.3101 fatcat:zllfihdulzhdjjmz6bat6pfmye