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Sensitive and robust UPLC–MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide
2011
Journal of Pharmaceutical and Biomedical Analysis
In this study, a sensitive and robust ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed, validated, and applied to determine gender-dependent pharmacokinetics of total emodin (aglycone+glucuronide) in male and female Sprague-Dawley rats. The lower limit of quantification for emodin and emodin glucuronide in rat plasma was 39 and 78 ng/ml, with signal-to-noise ratio of ≥ 10. Precision and accuracy studies showed emodin and emodin glucuronide plasma
doi:10.1016/j.jpba.2010.12.004
pmid:21195574
pmcid:PMC4010304
fatcat:ihtr3rfapzemzot7tn7lxjfm2q