Decreased plasma and tissue isoleucine levels after simulated gastrointestinal bleeding by blood gavages in chronic portacaval shunted rats

S W Olde Damink, C H Dejong, N E Deutz, P B Soeters
1997 Gut  
Background-Previously, arterial concentrations of the essential branched chain amino acid isoleucine (Ile) were found to have decreased by more than 50% after gastrointestinal haemorrhage in patients and after intragastric blood administration in healthy humans and pigs. Hypothetically, this induced hypoisoleucinaemia could deplete tissue Ile pools. Aims-To study the effect of repeated blood gavages on arterial and tissue Ile levels during normal and impaired liver funcion.
doi:10.1136/gut.40.3.418 fatcat:h7psehsewzevdis36pydhftq4y