Structure-based chemotherapy of SARS – where do we stand, three years after the global outbreak?

R. Hilgenfeld
2006 Acta Crystallographica Section A Foundations of Crystallography  
Three years have passed since the global outbreak of severe acute respiratory syndrome (SARS). During this time, major progress has been made in understanding the mechanisms of infection [1]. Three-dimensional structures have been determined for a number of non-structural and structural proteins of the virus and of related coronaviruses [2-5]. In the absence of a crystal structure for the viral RNA polymerase, the main proteinase remains the most suitable anti-coronaviral drug target [3, [6]
more » ... [8] [9] [10] . Progress in designing and synthesizing specific inhibitors for this enzyme will be reported.
doi:10.1107/s0108767306099867 fatcat:vbyapmy6yfcp5fnfiq7vv2p45i