Interrelationships Between Angiotensin, Norepinephrine, Epinephrine, Aldosterone Secretion, and Electrolyte Metabolism in Man

JOHN H. LARAGH
1962 Circulation  
to summarize for you some of our studies in man which suggest an interaction between the amide of synthetic valyl-5-angiotensin II, norepinephrine, aldosterone secretion, and sodium and potassium excretion by the kidney. The studies which I shall report were carried out in normal volunteers and in patients with hypertension or with cirrhosis and ascites. All studies were conducted under conlitions of controlled metabolism balance. Our interest in angiotensin developed as an outgrowth of a
more » ... utgrowth of a long-standing interest in aldosterone netabolism and in the factors concerned with the regulation of the rate of secretion of this hormonle. Therefore, I should tike first to review briefly some of our work on aldosterone secretion which resulted in our inivestigation of the relation of angiotensin to aldosteronie and to electrolyte balance. Aldosterone Oversecretion in Man Many studies of aldosterone have been based on quantitation of the small fraction of hormone excreted unchanlged in the urine. By contrast, our work has employed a technic of isotope dilution which measures with precision the amount of the hormone actually secreted by the adrenal cortex. Details of this method have been previously described. 1 We have found marked oversecretion of aldosterone in the edematous states of cirrhosis and nephrosis. Of interest was the finding that in advanced heart failure, aldosterone secretion may not be much elevated,2 pointing again to the fact that hemodynamie rather
doi:10.1161/01.cir.25.1.203 pmid:14462380 fatcat:izkmwinxvzcoppwainrzteujue