A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
Increasing Eukaryotic Initiation Factor 6 (eIF6) Gene Dosage Stimulates Global Translation and Induces a Transcriptional and Metabolic Rewiring that Blocks Programmed Cell Death
Increases in ribosomal proteins and initiation factors are often observed in tumours and required during development. Haploinsufficient models have shown that such elevation is essential for tumour growth. Models with increased gene dosage of initiation factors, addressing the effects of their forced overexpression are lacking. The eukaryotic Initiation Factor 6 (eIF6) gene is amplified in some cancers and overexpressed in most, while it has been demonstrated that eIF6 haploinsufficiencydoi:10.1101/201558 fatcat:csl4hcytdnekfilbe52rfxzagu