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This study analyses the regional health inequalities in the European macroregion, with particular emphasis on the mortality trends in East Central Europe. On one hand, our research aims focus on the territorial fragmentation of the examined area, the identification of main breaklines, and examination of mortality factors affecting differentiation. On the other hand, we identify the socioeconomic differentiation behind regional disparities in health status. According to our results, beyond thedoi:10.15196/rs0711 fatcat:hxmmk2lj4nhbznnqbj4tngkoe4