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The association of the prion protein (PrP) with sphingolipid-and cholesterol-rich lipid rafts is instrumental in the pathogenesis of the neurodegenerative prion diseases. Although the glycosylphosphatidylinositol (GPI) anchor is an exoplasmic determinant of raft association, PrP remained raft-associated in human neuronal cells even when the GPI anchor was deleted or substituted for a transmembrane anchor indicating that the ectodomain contains a raft localization signal. The raft association ofdoi:10.1074/jbc.m302036200 pmid:12865430 fatcat:mwyocp7aynbtti23afdi5xbnta