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Stromal and epithelial networks: Temporal gene expression profiling during invasive neoplasia
2009
Cell Adhesion & Migration
The interaction between tumor cells and the stromal microenvironment is a critical factor in cancer development and progression. A recent study from the Khavari group profiled the expression changes during progression to invasion in a Ras-inducible model of human epithelial neoplasia and used network modeling to analyze the molecular interactions. Human dermis was seeded with H-Ras- and IkappaBalpha-expressing keratinocytes then grafted on to immune-deficient mice. The epithelial and stromal
doi:10.4161/cam.3.4.9912
pmid:19829083
pmcid:PMC2802737
fatcat:anl7met7krad5mpjmkojz6xxyq