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Human and Chimpanzee Gene Expression Differences Replicated in Mice Fed Different Diets
2008
PLoS ONE
Although the human diet is markedly different from the diets of closely related primate species, the influence of diet on phenotypic and genetic differences between humans and other primates is unknown. In this study, we analyzed gene expression in laboratory mice fed diets typical of humans and of chimpanzees. The effects of human diets were found to be significantly different from that of a chimpanzee diet in the mouse liver, but not in the brain. Importantly, 10% of the genes that differ in
doi:10.1371/journal.pone.0001504
pmid:18231591
pmcid:PMC2200793
fatcat:xmqywffrqrcxredmz3odm354wi