Objective: To study the effect of radiofrequency-assisted hepatectomy treatment of primary liver cancer on cancer cell apoptosis and normal liver tissue damage. Methods: 50 patients with primary liver cancer who received surgery in our hospital between May 2011 and August 2015 were collected, their operation methods and test results were reviewed, and then they were divided into the control group (n=30) who received hepatectomy treatment alone and the observation group (n=20) who received

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... requency-assisted hepatectomy treatment. Intraoperative tumor tissue was collected to detect the proliferation and apoptosis gene mRNA expression by fluorescent quantitative PCR; 3 d after operation, serum was collected to detect serum liver enzyme index levels by immune scatter turbidimetry. Results: IFITM3, NCX1, CXCR2, Cep55 and Bcl-2 mRNA expression in liver cancer tissue of observation group were lower than those of control group while Caspase-3 and Cyt-C mRNA expression were higher than those of control group (P<0.05); 3 d after operation, serum liver enzyme indexes ALT, AKP and GGT levels of observation group were not significantly different from those of control group (P>0.05). Conclusion: Radiofrequency-assisted hepatectomy can effectively induce liver cancer cell apoptosis without increasing the normal liver tissue damage.