Immuno-Thrombotic Effects of Platelet Serotonin [chapter]

Elmina Mammadova-Bach, Maximilian Mauler, Attila Braun, Daniel Duerschmied
2017 Serotonin - A Chemical Messenger Between All Types of Living Cells  
Platelets transport and store serotonin at a high concentration in dense granules and release it upon activation. Abnormal serotonin concentrations in the blood plasma or increased platelet serotonin release promote the development of thrombosis, sepsis, allergic asthma, myocardial infarction, and stroke. Consequently, experimental data suggest possible benefits of serotonin receptor blockade or inhibition of platelet serotonin uptake in the indicated human diseases. Here, we highlight the
more » ... highlight the current state of basic biological research regarding the role of platelet serotonin in normal and pathophysiological conditions focusing on thrombotic and inflammatory diseases. We also describe the possible clinical applicability of targeting thrombo-immune-modulatory effects of platelet serotonin to treat common health problems.
doi:10.5772/intechopen.69349 fatcat:hfjuf4u2qncnblijl5ybl7imvy