Correlation of Cerebrospinal Fluid Sialic Acid with Various Enzymes in Patients with Meningitis

Nawal Abdullah Murtadha
2016 Journal of Environmental Science and Engineering B  
Meningitis is often associated with cerebral compromise which may be responsible for neurological squeal in nearly half of the survivors. Little is known about the mechanisms of Central Nervous System (CNS) involvement in bacterial meningitis. The present study was undertaken to assess the changes in biochemical parameters including glucose, protein, Sialic Acid (SA) and various enzymes like Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Creatine Kinase (CK), Gamma
more » ... nspeptidase γ (GGTP) and Lactate Dehydrogenase (LDH) have been determined in the Cerebrospinal Fluid (CSF) of the meningitis patients (n = 26) and compared with control subjects (n = 26). Total Protein, CK, SA (P < 0.02), AST (P < 0.001) and ALT (P < 0.0001) of meningitis patients were significantly higher, whereas, glucose (P < 0.05) and Gamma Glutamyltranspeptidase (GGT) (P < 0.01 and P < 0.05, respectively) were significantly lower than those of the controls. This study suggests that loss of integrity of brain-CSF barriers, sialic acid and enzyme profiles may contribute to the severity and neurological complications of meningitis.
doi:10.17265/2162-5263/2016.03.003 fatcat:vygngcucafhvhn56kmtw2w37oe