BACKGROUND: Insomnia is underappreciated public health issue. In recent years, insomnia treatment has advanced beyond the routine use of benzodiazepines. AIMS: To compare the efficacy and safety of low dose Doxepin with Zopiclone in patients with primary insomnia. SETTINGS AND DESIGN: A double blind, randomized parallel group, prospective study of low dose Doxepin (n=20) and Zopiclone (n=15) in patients with primary insomnia. METHODS & MATERIAL: Patients fulfilling the selection criteria were

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... rolled. Enrolled patients were randomized to 2 groups-of low dose Doxepin(3mg) and Zopiclone (3.75mg). Patients were provided with sleep diaries to record sleep parameters, change in alertness and mood, sleepiness scale score and other adverse events were recorded. STATISTICAL ANALYSIS: Student 't' test. RESULTS: Both the groups show significant reduction the time of wakening after sleep onset, with improvement in both total sleep time & sleep efficiency. Both the drugs were well tolerated and percentage change in mood and alertness was comparable. CONCLUSION: Low dose Doxepin was found to be as effective and safe as Zopiclone in patients of primary insomnia. HOW TO CITE THIS ARTICLE: Pali Rastogi, Deepti Rastogi. "A Double Blind, Randomized, Parallel Group, Prospective, Clinical Study for Evaluation of Efficacy and Safety of Low Dose Doxepin in Comparision