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Myeloid-Derived Suppressor Cells: Facilitators of Cancer and Obesity-Induced Cancer
Annual Review of Cancer Biology
Immature myeloid cells at varied stages of differentiation, known as myeloid-derived suppressor cells (MDSC), are present in virtually all cancer patients. MDSC are profoundly immune-suppressive cells that impair adaptive and innate antitumor immunity and promote tumor progression through nonimmune mechanisms. Their widespread presence combined with their multitude of protumor activities make MDSC a major obstacle to cancer immunotherapies. MDSC are derived from progenitor cells in the bonedoi:10.1146/annurev-cancerbio-042120-105240 fatcat:zqbxkvafrncq7ixtwu2fdw6wlm