EVIDENCE FOR IMMUNOSUPPRESSIVE PROPERTIES OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS

Wasin Charerntantanakul
unpublished
This study reviews evidence for immunosuppressive properties of porcine reproductive and respiratory syndrome virus (PRRSV). PRRSV induces poor innate and adaptive immune responses after infection. Innate immune response to PRRSV was reduced as determined by phagocytosis, production of reactive oxygen species, bacteri-cidal activity, and production of innate cytokines by pulmonary alveolar macrophages and pulmonary intravascular macrophages. Humoral immune response to PRRSV was weak and delayed
more » ... as compared to humoral immune response to other swine pathogens. The humoral immune response of PRRSV-infected pigs to other swine pathogens was significantly reduced during acute PRRSV infection. Cell-mediated immune response to PRRSV was weak and much delayed. The mechanisms of PRRSV affecting immune responses are not clearly understood. Chiang Mai Veterinary Journal 2007;5(1):17-28.
fatcat:vva7wmj5ebadlnh4y3cjn6cmvu