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This study reviews evidence for immunosuppressive properties of porcine reproductive and respiratory syndrome virus (PRRSV). PRRSV induces poor innate and adaptive immune responses after infection. Innate immune response to PRRSV was reduced as determined by phagocytosis, production of reactive oxygen species, bacteri-cidal activity, and production of innate cytokines by pulmonary alveolar macrophages and pulmonary intravascular macrophages. Humoral immune response to PRRSV was weak and delayedfatcat:vva7wmj5ebadlnh4y3cjn6cmvu