Dengue virus (DENV) infection is still a serious health problem in Indonesia. Community based dengue study to determine circulated DENV in certain place and time is limited due to expensive cost and effort. Many DENV infected patients are not admitted to the hospital, and many patients come to the hospital at later phase of disease. In this study, we developed active DENV cases finding in the community in Jakarta to study circulating dengue serotypes where adult febrile patients with fever less

more »

... than 48 hours were recruited. Disease severities were defined using the World Health Organization (WHO) 1997 guideline. Rapid NS1 dengue antigen detection were used to screen DENV patients in the community. Viral isolation in C6/36 cell line or increased antibody titer by HI and ELISA or RT-PCR were performed to confirm DENV infection.Viral serotype was investigated through RT-PCR. From 102 patients, 68 (66.7%) patients were confirmed DENV infection with DENV-2 is the most dominant serotype followed by DENV-3, DENV-1 and DENV-4, in concordance with several cases of mixed DENV infection. Interestingly, in terms of disease severity, although DENV-3 infection is not the predominant circulating serotype, but its infection tend to give more severe disease compare to DENV-2 infection.