A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf
.
Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics
[article]
2022
bioRxiv
pre-print
SummaryTP53 is the most commonly mutated gene in human cancer, typically occurring in association with complex cytogenetics and dismal outcomes. Understanding the genetic and non-genetic determinants of TP53-mutation driven clonal evolution and subsequent transformation is a crucial step towards the design of rational therapeutic strategies. Here, we carry out allelic resolution single-cell multi-omic analysis of haematopoietic stem/progenitor cells (HSPC) from patients with a
doi:10.1101/2022.03.28.485984
fatcat:xxwaqeegtzbs3cti7lmgnmufha